Article
Integrin CD103 expression in naive CD8+ T cells promotes cytokine-driven acquisition of memory phenotype and effector function.
Immunity - 11 Nov 2025
Li Can, Ligons Davinna L, Lanasa Dominic, Keller Hilary R, Luckey Megan A, Capaldo Brian, Meerzaman Daoud, Park Joo-Young, Park Jung-Hyun
Abstract excerpt
Integrin CD103 binds to E-cadherin, a cell adhesion molecule predominantly expressed on epithelial cells, thus mediating the tissue residency of CD103+ T cells in barrier sites. Importantly, circulating naive CD8+ T cells also express large amounts of CD103, but whether CD103 contributes to CD8+ T cell immunity beyond its role in cell adhesion is unclear. Here, we report that CD103 expression in naive CD8+ T...
Read the complete abstract on PubMedTopics
- Integrin alpha Chains
- Animals
- Antigens, CD
- Immunologic Memory
- Mice
- CD8-Positive T-Lymphocytes