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Article

E2F1 death pathways as targets for cancer therapy

1 Mar 2007

Abstract excerpt

Defects in apoptotic programs contribute to a number of human diseases, ranging from neurodegenerative disorders to malignancy, and treatment failure. The genetic basis for apoptosis implies that cell death can be disrupted by mutations, raising the intriguing possibility that cell numbers can be regulated by factors that influence cell survival. It is well documented that the E2F1 transcription factor is a key...

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PMID: 17488475
DOI: 10.1111/j.1582-4934.2007.00030.x

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