Article
Heterogeneity of p53 mutational status in the superficial spreading type of early gastric carcinoma.
Gastric cancer : official journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association - 1 Jan 2001
Iwamatsu H, Nishikura K, Watanabe H, Ajioka Y, Hashidate H, Kashimura H, Asakura H
Abstract excerpt
BACKGROUND: The superficial spreading type of gastric carcinoma may originate from either a single cellular clone or from several different clones; this issue remains controversial. Indeed, the p53 gene has been shown to play an important role in gastric carcinogenesis, but there have been only a few reports on the heterogeneity of gastric carcinoma with respect to the p53 gene. METHODS: We analyzed seven cases...
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