Maturation sensitive and resistant t(15;17) NB4 cell lines as tools for APL physiopathology: nomenclature of cells and repertory of their known genetic alterations and phenotypes.

doi:10.1038/sj.onc.1204863

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Article

Maturation sensitive and resistant t(15;17) NB4 cell lines as tools for APL physiopathology: nomenclature of cells and repertory of their known genetic alterations and phenotypes.

Oncogene - 29 Oct 2001

Roussel M J, Lanotte M

Abstract excerpt

Chromosomal translocations, leading to gene rearrangements that generate chimerical proteins, represent one of the initiating events of leukemia. Preleukemia cells eventually develop into overt leukemia by occurrence of secondary genetic alterations (tumor progression). The physiopathology of leukemia has made considerable progress during the last two decades, due to molecular biology investigations on the role...

Topics

Apoptosis
Arsenic Trioxide
Arsenicals
Cell Differentiation
Drug Resistance, Neoplasm
Humans
Leukemia, Promyelocytic, Acute
Oxides
Phenotype
Retinoids
Terminology as Topic
Transgenes
Tumor Cells, Cultured

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Open in PubMed

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PMID: 11704857
DOI: 10.1038/sj.onc.1204863

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026.

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