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Article

Bcl-2 is an apoptotic target suppressed by both c-Myc and E2F-1.

Oncogene - 25 Oct 2001

Eischen C M, Packham G, Nip J, Fee B E, Hiebert S W, Zambetti G P, Cleveland J L

Abstract excerpt

Malignant transformation occurs in cells that overexpress c-Myc or that inappropriately activate E2F-1. Transformation occurs after the selection of cells that have acquired resistance to apoptosis that is triggered by these oncogenes, and a key mediator of this cell death process is the p53 tumor suppressor. In IL-3-dependent immortal 32D.3 myeloid cells the ARF/p53 apoptotic pathway is inactivated, as these...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 11704823
DOI: 10.1038/sj.onc.1204892

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Bcl-2 is an apoptotic target suppressed by both c-Myc and E2F-1.PMID 11704823Read ↗

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