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Article

Cytogenetic and morphological abnormalities in paroxysmal nocturnal haemoglobinuria

1 Nov 2001

Abstract excerpt

Paroxysmal nocturnal haemoglobinuria (PNH) is characterized by the expansion of a haematopoietic stem cell clone with a PIG-A mutation (the PNH clone) in an environment in which normal stem cells are lost or failing: it has been hypothesized that this abnormal marrow environment provides a relative advantage to the PNH clone. In patients with PNH, generally, the karyotype of bone marrow cells has been reported to...

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PMID: 11703336
DOI: 10.1046/j.1365-2141.2001.03113.x

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