Article
Polymorphisms within the prion-like protein gene (Prnd) and their implications in human prion diseases, Alzheimer's disease and other neurological disorders.
Human genetics - 1 Sept 2001
Schröder B, Franz B, Hempfling P, Selbert M, Jürgens T, Kretzschmar H A, Bodemer M, Poser S, Zerr I
Abstract excerpt
Only 10% of human transmissible spongiform encephalopathies (TSEs) are associated with mutations of the Prnp region encoding the prion protein (PrP). Recently, the murine PrP-like protein doppel (Dpl) was described and was shown to be overexpressed in certain strains of PrP knockout mice and to cause neurological diseases such as ataxia and Purkinje cell loss. To answer the question of whether there are any...
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