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Article

Polymorphism at 3' UTR +28 of the prion-like protein gene is associated with sporadic Creutzfeldt-Jakob disease.

European journal of human genetics : EJHG - 1 Sept 2005

Jeong Byung-Hoon, Kim Nam-Ho, Choi Eun-Kyoung, Lee Chaeyoung, Song Young-Han, Kim Jae-Il, Carp Richard I, Kim Yong-Sun

Abstract excerpt

The downstream prion-like protein (doppel or Dpl) shares significant biochemical and structural homology with the cellular prion protein, PrP(C), which is considered as a responsible protein for the transmissible spongiform encephalopathies (TSEs) or prion diseases. Recently, polymorphisms in open reading frame (ORF) of the prion-like protein gene (PRND) have been analysed in relation to the occurrence of prion...

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Identifiers

PMID: 15986038
DOI: 10.1038/sj.ejhg.5201460

Genes

PRND

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Polymorphism at 3' UTR +28 of the prion-like protein gene is associated with sporadic Creutzfeldt-Jakob disease.PMID 15986038Read ↗

Polymorphisms within the prion-like protein gene (Prnd) and their implications in human prion diseases, Alzheimer's disease and other neurological disorders.Semantic proximity Read ↗

Polymorphisms at codons 56 and 174 of the prion-like protein gene (PRND) are not associated with sporadic Creutzfeldt-Jakob disease.Semantic proximity Read ↗

Polymorphisms in the prion protein gene and in the doppel gene increase susceptibility for Creutzfeldt-Jakob disease.Semantic proximity Read ↗

First report of polymorphisms in the prion-like protein gene (PRND): implications for human prion diseases.Semantic proximity Read ↗

Significant association of a M129V independent polymorphism in the 5′ UTR of the <i>PRNP</i> gene with sporadic Creutzfeldt-Jakob disease in a large German case-control studySemantic proximity Read ↗

Genotype patterns and characteristics of PRNP in the Korean population.Semantic proximity Read ↗

Genetic studies in human prion diseases.Semantic proximity Read ↗

Association of the PRNP regulatory region polymorphisms with the occurrence of sporadic Creutzfeldt-Jakob disease.Semantic proximity Read ↗

Polymorphisms of the prion protein gene (PRNP) in a Korean population.Semantic proximity Read ↗

Polymorphism at codon 174 of the prion-like protein gene is not associated with sporadic Alzheimer's disease.Semantic proximity Read ↗

Sporadic--but not variant--Creutzfeldt-Jakob disease is associated with polymorphisms upstream of PRNP exon 1.Semantic proximity Read ↗

PRNP contains both intronic and upstream regulatory regions that may influence susceptibility to Creutzfeldt-Jakob Disease.Semantic proximity Read ↗

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