Article
Genomic organization, comparative analysis, and genetic polymorphisms of the bovine and ovine prion Doppel genes (PRND).
Mammalian genome : official journal of the International Mammalian Genome Society - 1 Sept 2001
Comincini S, Foti M G, Tranulis M A, Hills D, Di Guardo G, Vaccari G, Williams J L, Harbitz I, Ferretti L
Abstract excerpt
The doppel protein (Dpl) is a prion-like protein encoded by the gene PRND, which has been found downstream of the prion gene, PRNP, in human and mouse. This paper describes the isolation and structural organization of the bovine and ovine PRND genes, which are composed of two exons compared with the three of human and mouse. Intergenic distances between PRNP and PRND were covered by means of long-range PCR and...
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