Article
Linkage of body mass index to chromosome 20 in Utah pedigrees.
Human genetics - 1 Sept 2001
Hunt S C, Abkevich V, Hensel C H, Gutin A, Neff C D, Russell D L, Tran T, Hong X, Jammulapati S, Riley R, Weaver-Feldhaus J, Macalma T, Richards M M, Gress R, Francis M, Thomas A, Frech G C, Adams T D, Shattuck D, Stone S
Abstract excerpt
Several linkage studies have hinted at the existence of an obesity predisposition locus on chromosome 20, but none of these studies has produced conclusive results. Therefore, we analyzed 48 genetic markers on chromosome 20 for linkage to severe obesity (BMI> or =35) in 103 extended Utah pedigrees (1,711 individuals), all of which had strong aggregation of severe obesity. A simple dominant model produced a...
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