Article
Hypermethylation trigger of the glutathione-S-transferase gene (GSTP1) in prostate cancer cells.
Oncogene - 7 Feb 2002
Song Jenny Z, Stirzaker Clare, Harrison Janet, Melki John R, Clark Susan J
Abstract excerpt
Understanding what triggers hypermethylation of tumour suppressor genes in cancer cells is critical if we are to discern the role of methylation in the oncogenic process. CpG sites in CpG island promoters, that span most tumour suppressor genes, remain unmethylated in the normal cell, despite the fact that CpG sites are the prime target for de novo methylation by the DNA methyltransferases. The CpG...
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