Article
Detailed methylation analysis of the glutathione S-transferase pi (GSTP1) gene in prostate cancer.
Oncogene - 11 Feb 1999
Millar D S, Ow K K, Paul C L, Russell P J, Molloy P L, Clark S J
Abstract excerpt
Glutathione-S-Transferases (GSTs) comprise a family of isoenzymes that provide protection to mammalian cells against electrophilic metabolites of carcinogens and reactive oxygen species. Previous studies have shown that the CpG-rich promoter region of the pi-class gene GSTP1 is methylated at single restriction sites in the majority of prostate cancers. In order to understand the nature of abnormal methylation of...
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