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Article

Direct association of Bloom's syndrome gene product with the human mismatch repair protein MLH1.

Nucleic acids research - 1 Nov 2001

Pedrazzi G, Perrera C, Blaser H, Kuster P, Marra G, Davies S L, Ryu G H, Freire R, Hickson I D, Jiricny J, Stagljar I

Abstract excerpt

Bloom's syndrome (BS) is a rare genetic disorder characterised by genomic instability and cancer susceptibility. BLM, the gene mutated in BS, encodes a member of the RecQ family of DNA helicases. Here, we identify hMLH1, which is involved in mismatch repair (MMR) and recombination, as a protein t...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Open in PubMed Open full text

Identifiers

PMID: 11691925
DOI: 10.1093/nar/29.21.4378
PMCID: PMC60193

Genes

BLM
MLH1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-11691925-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Direct association of Bloom's syndrome gene product with the human mismatch repair protein MLH1.PMID 11691925Read ↗

The Bloom's Syndrome Helicase Interacts Directly with the Human DNA Mismatch Repair Protein hMSH6Semantic proximity Read ↗

The Bloom's syndrome protein (BLM) interacts with MLH1 but is not required for DNA mismatch repair.Semantic proximity Read ↗

Potential role for the BLM helicase in recombinational repair via a conserved interaction with RAD51.Semantic proximity Read ↗

Genomic instability and cancer: lessons from analysis of Bloom's syndrome.Semantic proximity Read ↗

RECQ-like helicases Sgs1 and BLM regulate R-loop–associated genome instabilitySemantic proximity Read ↗

Intra-nuclear trafficking of the BLM helicase to DNA damage-induced foci is regulated by SUMO modification.Semantic proximity Read ↗

Conserved roles of RECQ-like helicases Sgs1 and BLM in preventing R-loop associated genome instabilitySemantic proximity Read ↗

Evidence for BLM and Topoisomerase IIIalpha interaction in genomic stability.Semantic proximity Read ↗

Depletion of the bloom syndrome helicase stimulates homology-dependent repair at double-strand breaks in human chromosomes.Semantic proximity Read ↗

Role of the Bloom's syndrome helicase in maintenance of genome stability.Semantic proximity Read ↗

The DNA helicase activity of BLM is necessary for the correction of the genomic instability of bloom syndrome cells.Semantic proximity Read ↗

Regulation and Localization of the Bloom Syndrome Protein in Response to DNA DamageSemantic proximity Read ↗

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