Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Saccharomyces cerevisiae pms2 mutations are alleles of MLH1, and pms2-2 corresponds to a hereditary nonpolyposis colorectal carcinoma-causing missense mutation.

Molecular and cellular biology - 1 Jun 1996

Jeyaprakash A, Das Gupta R, Kolodner R

Abstract excerpt

A number of mutant Saccharomyces cerevisiae strains having phenotypes consistent with defects in DNA mismatch repair have been described, but not all have been extensively characterized. In this study we demonstrate that the pms2-1 and pms2-2 alleles arise from missense mutations in the MLH1 gene which inactivate MLH1. One of these alleles, pms2-2, causes the same amino acid substitution in a highly conserved...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Alleles
Share to Amino Acid Sequence

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Base Sequence

Share to DNA Primers

Share to Models, Genetic

Share to Molecular Sequence Data

Share to Mutation

Share to Phenotype

Source

Open in PubMed Open full text

Identifiers

PMID: 8649412
DOI: 10.1128/MCB.16.6.3008
PMCID: PMC231295

Genes

MLH1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Saccharomyces cerevisiae pms2 mutations are alleles of MLH1, and pms2-2 corresponds to a hereditary nonpolyposis colorectal carcinoma-causing missense mutation.PMID 8649412Read ↗

Mutations predisposing to hereditary nonpolyposis colorectal cancer.Semantic proximity Read ↗

Functional domains of the Saccharomyces cerevisiae Mlh1p and Pms1p DNA mismatch repair proteins and their relevance to human hereditary nonpolyposis colorectal cancer-associated mutations.Semantic proximity Read ↗

Mutation sharing, predominant involvement of the MLH1 gene and description of four novel mutations in hereditary nonpolyposis colorectal cancer. Mutations in brief no. 144. Online.Semantic proximity Read ↗

Functional characterization of pathogenic human MSH2 missense mutations in Saccharomyces cerevisiae.Semantic proximity Read ↗

Human MutL homolog (MLH1) function in DNA mismatch repair: a prospective screen for missense mutations in the ATPase domainSemantic proximity Read ↗

The effect of genetic background on the function of Saccharomyces cerevisiae mlh1 alleles that correspond to HNPCC missense mutations.Semantic proximity Read ↗

Assessing pathogenicity of MLH1 variants by co-expression of human MLH1 and PMS2 genes in yeast.Semantic proximity Read ↗

Mutator phenotypes of common polymorphisms and missense mutations in MSH2.Semantic proximity Read ↗

Lynch syndrome-associated mutations in MSH2 alter DNA repair and checkpoint response functions in vivo.Semantic proximity Read ↗

Functional analysis of human MLH1 and MSH2 missense variants and hybrid human-yeast MLH1 proteins in Saccharomyces cerevisiaeSemantic proximity Read ↗

Negative epistasis between natural variants of the Saccharomyces cerevisiae MLH1 and PMS1 genes results in a defect in mismatch repair.Semantic proximity Read ↗

Humanizing mismatch repair in yeast: towards effective identification of hereditary non-polyposis colorectal cancer alleles.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.