Article
Saccharomyces cerevisiae pms2 mutations are alleles of MLH1, and pms2-2 corresponds to a hereditary nonpolyposis colorectal carcinoma-causing missense mutation.
Molecular and cellular biology - 1 Jun 1996
Jeyaprakash A, Das Gupta R, Kolodner R
Abstract excerpt
A number of mutant Saccharomyces cerevisiae strains having phenotypes consistent with defects in DNA mismatch repair have been described, but not all have been extensively characterized. In this study we demonstrate that the pms2-1 and pms2-2 alleles arise from missense mutations in the MLH1 gene...
Topics
- Adaptor Proteins, Signal Transducing
- Alleles
- Amino Acid Sequence
- Base Sequence
- Colorectal Neoplasms, Hereditary Nonpolyposis
- Conserved Sequence
- DNA Primers
- DNA Repair
- DNA, Fungal
- DNA, Neoplasm
- Fungal Proteins
- Genes, Fungal
- Humans
- Models, Genetic
- Molecular Sequence Data