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Article

Analysis of p300 acetyltransferase substrate specificity by MALDI TOF mass spectrometry.

Methods (San Diego, Calif.) - 1 Aug 2005

Dormeyer Wilma, Ott Melanie, Schnölzer Martina

Abstract excerpt

Acetyltransferase enzymes target specific lysine residues in substrate proteins. While the list of histone and nonhistone substrates is growing, the mechanisms of substrate selection remain unclear. Here, we describe a mass spectrometric approach to examine the site selection of the acetyltransferase p300 in the HIV-1 protein Tat. Tat is acetylated by p300 at a single lysine (K50) within its basic RNA-binding...

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Share to Acetylation
Share to Acetyltransferases
Share to Consensus Sequence

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Gene Products, tat

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Share to p300-CBP Transcription Factors

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Share to Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization

Source

Identifiers

PMID: 16085422
DOI: 10.1016/j.ymeth.2005.03.006

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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