Article
A novel Rtg2p activity regulates nitrogen catabolism in yeast.
Proceedings of the National Academy of Sciences of the United States of America - 6 Nov 2001
Pierce M M, Maddelein M L, Roberts B T, Wickner R B
Abstract excerpt
The inactivity of Ure2p, caused by either a ure2 mutation or the presence of the [URE3] prion, increases DAL5 transcription and thus enables Saccharomyces cerevisiae to take up ureidosuccinate (USA+). Rtg2p regulates transcription of glutamate-repressible genes by facilitation of the nuclear entry of the Rtg1 and Rtg3 proteins. We find that rtg2 Delta cells take up USA even without the presence of [URE3]. Thus,...
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