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Article

Coexpression of the CUG-binding protein reduces DM protein kinase expression in COS cells.

Journal of biochemistry - 1 Nov 2001

Takahashi N, Sasagawa N, Usuki F, Kino Y, Kawahara H, Sorimachi H, Maeda T, Suzuki K, Ishiura S

Abstract excerpt

Myotonic dystrophy (DM) is the most common form of adult onset muscular dystrophy. Patients have a large CTG repeat expansion in the 3' untranslated region of the DMPK gene, which encodes DM protein kinase. RNA trans-dominant models, which hypothesize that the expanded CUG trinucleotide repeat on DMPK mRNA sequesters a factor or disrupts the RNA metabolism of the DMPK mRNA itself and other mRNAs in a trans...

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Source

Identifiers

PMID: 11686919
DOI: 10.1093/oxfordjournals.jbchem.a003022

Genes

DMPK

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Coexpression of the CUG-binding protein reduces DM protein kinase expression in COS cells.PMID 11686919Read ↗

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Myotonic dystrophy: the role of the CUG triplet repeats in splicing of a novel DMPK exon and altered cytoplasmic DMPK mRNA isoform ratios.Semantic proximity Read ↗

RNA CUG Repeats Sequester CUGBP1 and Alter Protein Levels and Activity of CUGBP1Semantic proximity Read ↗

Pathogenic mechanisms of myotonic dystrophy.Semantic proximity Read ↗

Identification of a (CUG)n Triplet Repeat RNA-Binding Protein and Its Expression in Myotonic DystrophySemantic proximity Read ↗

Myotonic dystrophy: RNA pathogenesis comes into focus.Semantic proximity Read ↗

Myotonic dystrophy in transgenic mice expressing an expanded CUG repeat.Semantic proximity Read ↗

The myotonic dystrophy expanded CUG repeat tract is necessary but not sufficient to disrupt C2C12 myoblast differentiation.Semantic proximity Read ↗

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Mutant DMPK 3'-UTR transcripts disrupt C2C12 myogenic differentiation by compromising MyoD.Semantic proximity Read ↗

Expansion of a CUG trinucleotide repeat in the 3' untranslated region of myotonic dystrophy protein kinase transcripts results in nuclear retention of transcripts.Semantic proximity Read ↗

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