Mutant DMPK 3'-UTR transcripts disrupt C2C12 myogenic differentiation by compromising MyoD.

doi:10.1083/jcb.200206020

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Article

Mutant DMPK 3'-UTR transcripts disrupt C2C12 myogenic differentiation by compromising MyoD.

The Journal of cell biology - 11 Nov 2002

Amack Jeffrey D, Reagan Shannon R, Mahadevan Mani S

Abstract excerpt

Myotonic dystrophy (DM) is caused by two similar noncoding repeat expansion mutations (DM1 and DM2). It is thought that both mutations produce pathogenic RNA molecules that accumulate in nuclear foci. The DM1 mutation is a CTG expansion in the 3' untranslated region (3'-UTR) of dystrophia myotonica protein kinase (DMPK). In a cell culture model, mutant transcripts containing a (CUG)200 DMPK 3'-UTR disrupt C2C12...

Topics

3' Untranslated Regions
Animals
Cell Differentiation
Cells, Cultured
DNA-Binding Proteins
Gene Expression Regulation, Developmental
Genes, Reporter
Humans
In Situ Hybridization, Fluorescence
Mice
Models, Biological

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Muscle Proteins

Mutation

MyoD Protein

Myoblasts

Myogenic Regulatory Factor 5

Myogenin

Myotonic Dystrophy

Source

Open in PubMed Open full text

Identifiers

PMID: 12427866
DOI: 10.1083/jcb.200206020
PMCID: PMC2173077

Genes

DMPK

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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Mutant DMPK 3'-UTR transcripts disrupt C2C12 myogenic differentiation by compromising MyoD.PMID 12427866Read ↗

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