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Article

Identification of a (CUG)n Triplet Repeat RNA-Binding Protein and Its Expression in Myotonic Dystrophy

1 Nov 1996

Abstract excerpt

Myotonic dystrophy (DM) is an autosomal dominant neuromuscular disease that is associated with a (CTG)n repeat expansion in the 3'-untranslated region of the myotonin protein kinase (Mt-PK) gene. This study reports the isolation and characterization of a (CUG)n triplet repeat pre-mRNA/mRNA binding protein that may play an important role in DM pathogenesis. Two HeLa cell proteins, CUG-BP1 and CUG-BP2, have been...

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Identifiers

PMID: 8948631
DOI: 10.1093/nar/24.22.4407

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

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Identification of a (CUG)n Triplet Repeat RNA-Binding Protein and Its Expression in Myotonic DystrophyPMID 8948631Read ↗

RNA CUG Repeats Sequester CUGBP1 and Alter Protein Levels and Activity of CUGBP1Semantic proximity Read ↗

Visualization of double-stranded RNAs from the myotonic dystrophy protein kinase gene and interactions with CUG-binding proteinSemantic proximity Read ↗

Myotonic dystrophy: the role of the CUG triplet repeats in splicing of a novel DMPK exon and altered cytoplasmic DMPK mRNA isoform ratios.Semantic proximity Read ↗

Cardiac elav-type RNA-binding protein (ETR-3) binds to RNA CUG repeats expanded in myotonic dystrophySemantic proximity Read ↗

Disruption of splicing regulated by a CUG-binding protein in myotonic dystrophy.Semantic proximity Read ↗

Coexpression of the CUG-binding protein reduces DM protein kinase expression in COS cells.Semantic proximity Read ↗

Myotonic Dystrophy: The Role of RNA CUG Triplet RepeatsSemantic proximity Read ↗

Expansion of a CUG trinucleotide repeat in the 3' untranslated region of myotonic dystrophy protein kinase transcripts results in nuclear retention of transcripts.Semantic proximity Read ↗

RNA Foci, CUGBP1, and ZNF9 are the primary targets of the mutant CUG and CCUG repeats expanded in myotonic dystrophies type 1 and type 2.Semantic proximity Read ↗

DDX6 regulates sequestered nuclear CUG-expanded DMPK-mRNA in dystrophia myotonica type 1Semantic proximity Read ↗

The structural basis of myotonic dystrophy from the crystal structure of CUG repeatsSemantic proximity Read ↗

Ribonuclear inclusions in skeletal muscle in myotonic dystrophy types 1 and 2.Semantic proximity Read ↗

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