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Article

Myotonic dystrophy in transgenic mice expressing an expanded CUG repeat.

Science (New York, N.Y.) - 8 Sept 2000

Mankodi A, Logigian E, Callahan L, McClain C, White R, Henderson D, Krym M, Thornton C A

Abstract excerpt

Myotonic dystrophy (DM), the most common form of muscular dystrophy in adult humans, results from expansion of a CTG repeat in the 3' untranslated region of the DMPK gene. The mutant DMPK messenger RNA (mRNA) contains an expanded CUG repeat and is retained in the nucleus. We have expressed an untranslated CUG repeat in an unrelated mRNA in transgenic mice. Mice that expressed expanded CUG repeats developed...

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Source

Identifiers

PMID: 10976074
DOI: 10.1126/science.289.5485.1769

Genes

DMPK

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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