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Article

Molecular Basis for Impaired Muscle Differentiation in Myotonic Dystrophy

1 Oct 2001

Abstract excerpt

Differentiation of skeletal muscle is affected in myotonic dystrophy (DM) patients. Analysis of cultured myoblasts from DM patients shows that DM myoblasts lose the capability to withdraw from the cell cycle during differentiation. Our data demonstrate that the expression and activity of the proteins responsible for cell cycle withdrawal are altered in DM muscle cells. Skeletal muscle cells from DM patients fail...

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Identifiers

PMID: 11564876
DOI: 10.1128/mcb.21.20.6927-6938.2001

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