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Article

The myotonic dystrophy expanded CUG repeat tract is necessary but not sufficient to disrupt C2C12 myoblast differentiation.

Human molecular genetics - 1 Sept 2001

Amack J D, Mahadevan M S

Abstract excerpt

Myotonic dystrophy type 1 (DM1) is a dominant neuromuscular disorder caused by a trinucleotide (CTG) repeat expansion. Mutant DMPK 3'-untranslated region (3'-UTR) transcripts aggregate in nuclear foci and are thought to impose dominant-negative effects by interacting with RNA binding proteins. We demonstrated previously that the mutant 3'-UTR RNA disrupted C2C12 myoblast differentiation, and that the CUG...

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Source

Identifiers

PMID: 11555624
DOI: 10.1093/hmg/10.18.1879

Genes

DMPK

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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The myotonic dystrophy expanded CUG repeat tract is necessary but not sufficient to disrupt C2C12 myoblast differentiation.PMID 11555624Read ↗

Mutant DMPK 3'-UTR transcripts disrupt C2C12 myogenic differentiation by compromising MyoD.Semantic proximity Read ↗

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Visualization of double-stranded RNAs from the myotonic dystrophy protein kinase gene and interactions with CUG-binding proteinSemantic proximity Read ↗

Expansion of a CUG trinucleotide repeat in the 3' untranslated region of myotonic dystrophy protein kinase transcripts results in nuclear retention of transcripts.Semantic proximity Read ↗

DM2 intronic expansions: evidence for CCUG accumulation without flanking sequence or effects on ZNF9 mRNA processing or protein expression.Semantic proximity Read ↗

RNA Interference Targeting CUG Repeats in a Mouse Model of Myotonic DystrophySemantic proximity Read ↗

In vivo co-localisation of MBNL protein with DMPK expanded-repeat transcriptsSemantic proximity Read ↗

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