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Article

Cis and trans effects of the myotonic dystrophy (DM) mutation in a cell culture model

1 Oct 1999

Abstract excerpt

The mutation causing myotonic dystrophy (DM) has been identified as a CTG expansion in the 3'-untranslated region (3'-UTR) of the DM protein kinase gene ( DMPK ), but the mechanism(s) of pathogenesis remain unknown. Studies using DM patient materials have often produced confusing results. Therefore, to study the effects of the DM mutation in a controlled environment, we have established a cell culture model...

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Identifiers

PMID: 10484765
DOI: 10.1093/hmg/8.11.1975

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Source receipt: pubmed, retrieved 7 Sept 2026.

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Cis and trans effects of the myotonic dystrophy (DM) mutation in a cell culture modelPMID 10484765Read ↗

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