Article
Zebrafish colourless encodes sox10 and specifies non-ectomesenchymal neural crest fates.
Development (Cambridge, England) - 1 Nov 2001
Dutton K A, Pauliny A, Lopes S S, Elworthy S, Carney T J, Rauch J, Geisler R, Haffter P, Kelsh R N
Abstract excerpt
Waardenburg-Shah syndrome combines the reduced enteric nervous system characteristic of Hirschsprung's disease with reduced pigment cell number, although the cell biological basis of the disease is unclear. We have analysed a zebrafish Waardenburg-Shah syndrome model. We show that the colourless gene encodes a sox10 homologue, identify sox10 lesions in mutant alleles and rescue the mutant phenotype by ectopic...
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