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Article

Rescue of neural crest-derived phenotypes in a zebrafish CHARGE model by Sox10 downregulation.

Human molecular genetics - 15 Aug 2016

Asad Zainab, Pandey Aditi, Babu Aswini, Sun Yuhan, Shevade Kaivalya, Kapoor Shruti, Ullah Ikram, Ranjan Shashi, Scaria Vinod, Bajpai Ruchi, Sachidanandan Chetana

Abstract excerpt

CHD7 mutations are implicated in a majority of cases of the congenital disorder, CHARGE syndrome. CHARGE, an autosomal dominant syndrome, is known to affect multiple tissues including eye, heart, ear, craniofacial nerves and skeleton and genital organs. Using a morpholino-antisense-oligonucleotide-based zebrafish model for CHARGE syndrome, we uncover a complex spectrum of abnormalities in the neural crest and the...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 27418670
DOI: 10.1093/hmg/ddw198
PMCID: PMC5179949

Genes

CHD7

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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Rescue of neural crest-derived phenotypes in a zebrafish CHARGE model by Sox10 downregulation.PMID 27418670Read ↗

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