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Article

A zebrafish model for Waardenburg syndrome type IV reveals diverse roles for Sox10 in the otic vesicle.

Disease models & mechanisms - 1 Jan 2000

Dutton Kirsten, Abbas Leila, Spencer Joanne, Brannon Claire, Mowbray Catriona, Nikaido Masataka, Kelsh Robert N, Whitfield Tanya T

Abstract excerpt

In humans, mutations in the SOX10 gene are a cause of the auditory-pigmentary disorder Waardenburg syndrome type IV (WS4) and related variants. SOX10 encodes an Sry-related HMG box protein essential for the development of the neural crest; deafness in WS4 and other Waardenburg syndromes is usually attributed to loss of neural-crest-derived melanocytes in the stria vascularis of the cochlea. However, SOX10 is...

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Identifiers

PMID: 19132125
DOI: 10.1242/dmm.001164
PMCID: PMC2615172

Genes

SOX10

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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A zebrafish model for Waardenburg syndrome type IV reveals diverse roles for Sox10 in the otic vesicle.PMID 19132125Read ↗

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