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Article

Recruitment of Mec1 and Ddc1 checkpoint proteins to double-strand breaks through distinct mechanisms.

Science (New York, N.Y.) - 26 Oct 2001

Kondo T, Wakayama T, Naiki T, Matsumoto K, Sugimoto K

Abstract excerpt

In response to DNA damage, eukaryotic cells activate checkpoint pathways that arrest cell cycle progression and induce the expression of genes required for DNA repair. In budding yeast, the homothallic switching (HO) endonuclease creates a site-specific double-strand break at the mating type (MAT) locus. Continuous HO expression results in the phosphorylation of Rad53, which is dependent on products of the ataxia...

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Share to Checkpoint Kinase 2
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Share to Deoxyribonucleases, Type II Site-Specific

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 11679674
DOI: 10.1126/science.1063827

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Recruitment of Mec1 and Ddc1 checkpoint proteins to double-strand breaks through distinct mechanisms.PMID 11679674Read ↗

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Requirement of the Mre11 complex and exonuclease 1 for activation of the Mec1 signaling pathway.Semantic proximity Read ↗

The DNA damage-inducible UbL-UbA protein Ddi1 participates in Mec1-mediated degradation of Ho endonuclease.Semantic proximity Read ↗

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RAD53, DUN1 and PDS1 define two parallel G2/M checkpoint pathways in budding yeast.Semantic proximity Read ↗

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