Article
Lack of association between atopic eczema and the genetic variants of interleukin-4 and the interleukin-4 receptor alpha chain gene: heterogeneity of genetic backgrounds on immunoglobulin E production in atopic eczema patients.
Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology - 1 Oct 2001
Tanaka K, Sugiura H, Uehara M, Hashimoto Y, Donnelly C, Montgomery D S
Abstract excerpt
BACKGROUND: The genetic background of atopic eczema might be heterogeneous and there is a possibility that immunoglobulin (Ig)E responsiveness in patients with atopic eczema is controlled separately from the development of atopic eczema. Although both interleukin (IL)-4 and the IL-4 receptor alpha chain have an important role for IgE production and are therefore possible candidate genes for atopy, it has not been...
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