Article
Mutation analysis of interleukin-5 in an asthmatic cohort.
Human mutation - 1 Jan 1998
Pereira E, Goldblatt J, Rye P, Sanderson C, Le Souëf P
Abstract excerpt
Interleukin-5 (IL-5) is a potential candidate gene in the pathogenesis of asthma, as it is the main cytokine controlling eosinophil activity and eosinophils are pivotal in the development of airway inflammation. Mutation detection studies were performed on the IL-5 gene and the alpha-chain of its receptor in 30 asthmatic and 30 nonasthmatic subjects. Single-strand conformational polymorphism (SSCP) and...
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