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Article

Folding and self-assembly of herpes simplex virus type 1 thymidine kinase.

Journal of molecular biology - 26 Oct 2001

Wurth C, Thomas R M, Folkers G, Scapozza L

Abstract excerpt

Thymidine kinase from herpes simplex virus type 1 (HSV1 TK) has been postulated to be a homodimer throughout the X-ray crystallography literature. Our study shows that HSV1 TK exists as a monomer-dimer equilibrium mixture in dilute aqueous solutions. In the presence of 150 mM NaCl, the equilibrium is characterized by a dissociation constant of 2.4 microm; this constant was determined by analytical...

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PMID: 11676546
DOI: 10.1006/jmbi.2001.5060

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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