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Article

Revealing the dimer dissociation and existence of a folded monomer of the mature HIV-2 protease.

Protein science : a publication of the Protein Society - 1 Dec 2009

Louis John M, Ishima Rieko, Aniana Annie, Sayer Jane M

Abstract excerpt

Purification and in vitro protein-folding schemes were developed to produce monodisperse samples of the mature wild-type HIV-2 protease (PR2), enabling a comprehensive set of biochemical and biophysical studies to assess the dissociation of the dimeric protease. An E37K substitution in PR2 significantly retards autoproteolytic cleavage during expression. Furthermore, it permits convenient measurement of the dimer...

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Identifiers

PMID: 19798742
DOI: 10.1002/pro.261
PMCID: PMC2821264

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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