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Article

In vitro dimerization of the bovine papillomavirus E5 protein transmembrane domain.

Biochemistry - 26 Aug 2008

Oates Joanne, Hicks Matthew, Dafforn Timothy R, DiMaio Daniel, Dixon Ann M

Abstract excerpt

The E5 protein from bovine papillomavirus is a type II membrane protein and the product of the smallest known oncogene. E5 causes cell transformation by binding and activating the platelet-derived growth factor beta receptor (PDGFbetaR). In order to productively interact with the receptor, it is thought that E5 binds as a dimer. However, wild-type E5 and various mutants have also been shown to form trimers,...

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PMID: 18672907
DOI: 10.1021/bi8006252
PMCID: PMC3711124

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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