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Article

Head circumference and incident Alzheimer's disease: modification by apolipoprotein E.

Neurology - 23 Oct 2001

Borenstein Graves A, Mortimer J A, Bowen J D, McCormick W C, McCurry S M, Schellenberg G D, Larson E B

Abstract excerpt

BACKGROUND: The clinical expression of AD likely occurs when the accumulation of degeneration in specific brain regions leads to the descent below a critical threshold of "brain reserve" beyond which normal cognitive function cannot be maintained. The association between head circumference (HC), a measure of brain reserve, and the incidence of probable AD was examined in a large nondemented cohort that has been...

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Source

Identifiers

PMID: 11673588
DOI: 10.1212/wnl.57.8.1453

Genes

APOE

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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