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Article

Requirement for PAK4 in the Anchorage-independent Growth of Human Cancer Cell Lines

1 Jan 2002

Abstract excerpt

p21-activated protein kinase (PAK) serine/threonine kinases are important effectors of Rho family GTPases and have been implicated in the regulation of cell morphology and motility, as well as in cell transformation. To further investigate the possible involvement of PAK kinases in tumorigenesis, we analyzed the expression of several family members in tumor cell lines. Here we demonstrate that PAK4 is frequently...

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PMID: 11668177
DOI: 10.1074/jbc.m105732200

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