Article
P21-activated protein kinase (PAK2)-mediated c-Jun phosphorylation at 5 threonine sites promotes cell transformation.
Carcinogenesis - 1 May 2011
Li Tingting, Zhang Jishuai, Zhu Feng, Wen Weihong, Zykova Tatyana, Li Xiang, Liu Kangdong, Peng Cong, Ma Weiya, Shi Guozheng, Dong Ziming, Bode Ann M, Dong Zigang
Abstract excerpt
The oncoprotein c-Jun is one of the components of the activator protein-1 (AP-1) transcription factor complex. AP-1 regulates the expression of many genes and is involved in a variety of biological functions such as cell transformation, proliferation, differentiation and apoptosis. AP-1 activates a variety of tumor-related genes and therefore promotes tumorigenesis and malignant transformation. Here, we found...
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