Article
Analysis of the insulin-sensitive phosphodiesterase 3B gene in type 2 diabetes.
Diabetes research and clinical practice - 1 Nov 2001
Sano R, Miki T, Suzuki Y, Shimada F, Taira M, Kanatsuka A, Makino H, Hashimoto N, Saito Y
Abstract excerpt
We screened for mutations in the gene of insulin-sensitive phosphodiesterase 3B (PDE3B), which regulates antilipolytic actions of insulin via reduction of intracellular cyclic AMP levels, in Japanese patients with type 2 diabetes mellitus and lipoatrophic diabetes mellitus using single-stranded conformation polymorphism analysis and Southern analysis and investigated frequencies of variable number of tandem...
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