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Article

The RNA of the glutamate transporter EAAT2 is variably spliced in amyotrophic lateral sclerosis and normal individuals.

Journal of the neurological sciences - 15 Nov 1999

Meyer T, Fromm A, Münch C, Schwalenstöcker B, Fray A E, Ince P G, Stamm S, Grön G, Ludolph A C, Shaw P J

Abstract excerpt

Impaired re-uptake of synaptic glutamate, and a reduced expression of the glutamate transporter EAAT2 have been found in the motor cortex of patients with amyotrophic lateral sclerosis (ALS). Two splice forms of the EAAT2 RNA resulting from retention of intronic sequences (EAAT2/Int) and deletion of one protein coding exon (EAAT2/C1) have been reported to account for the EAAT2 protein loss in ALS. In this study...

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Identifiers

PMID: 10540035
DOI: 10.1016/s0022-510x(99)00196-3

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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