Article
The role of endothelin-1 in strain-related susceptibility to develop hypoxic pulmonary hypertension in rats.
Respiration physiology - 1 Nov 2001
Karamsetty M R, Pietras L, Klinger J R, Lanzillo J J, Leiter J C, Ou L C, Hill N S
Abstract excerpt
The Hilltop (H) strain compared to the Madison (M) strain of Sprague-Dawley rats develops severe pulmonary hypertension in response to chronic hypoxia. We tested the hypothesis that endothelin-1 (ET-1) contributes to these strain-related differences. Plasma ET-1 content was not modified by chronic hypoxia in either strain. The lung ET-1 peptide and preproET-1 mRNA content were significantly increased to the same...
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