Article
A high proportion of founder BRCA1 mutations in Polish breast cancer families.
International journal of cancer - 10 Jul 2004
Górski Bohdan, Jakubowska Anna, Huzarski Tomasz, Byrski Tomasz, Gronwald Jacek, Grzybowska Ewa, Mackiewicz Andrzej, Stawicka Malgorzata, Bebenek Marek, Sorokin Dagmara, Fiszer-Maliszewska Łucja, Haus Olga, Janiszewska Hanna, Niepsuj Stanisław, Góźdź Stanisław, Zaremba Lech, Posmyk Michał, Płuzańska Maria, Kilar Ewa, Czudowska Dorota, Waśko Bernard, Miturski Roman, Kowalczyk Jerzy R, Urbański Krzysztof, Szwiec Marek, Koc Jan, Debniak Bogusław, Rozmiarek Andrzej, Debniak Tadeusz, Cybulski Cezary, Kowalska Elzbieta, Tołoczko-Grabarek Aleksandra, Zajaczek Stanisław, Menkiszak Janusz, Medrek Krzysztof, Masojć Bartłomiej, Mierzejewski Marek, Narod Steven Alexander, Lubiński Jan
Abstract excerpt
Three mutations in BRCA1 (5382insC, C61G and 4153delA) are common in Poland and account for the majority of mutations identified to date in Polish breast and breast-ovarian cancer families. It is not known, however, to what extent these 3 founder mutations account for all of the BRCA mutations distributed throughout the country. This question has important implications for health policy and the design of...
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