BRCA1-related breast cancer in Austrian breast and ovarian cancer families: specific BRCA1 mutations and pathological characteristics.

doi:10.1002/(sici)1097-0215(19980729)77:3<354::aid-ijc8>3.0.co;2-n

Article

BRCA1-related breast cancer in Austrian breast and ovarian cancer families: specific BRCA1 mutations and pathological characteristics.

International journal of cancer - 29 Jul 1998

Wagner T M, Möslinger R A, Muhr D, Langbauer G, Hirtenlehner K, Concin H, Doeller W, Haid A, Lang A H, Mayer P, Ropp E, Kubista E, Amirimani B, Helbich T, Becherer A, Scheiner O, Breiteneder H, Borg A, Devilee P, Oefner P, Zielinski C

Abstract excerpt

We identified 17 BRCA1 mutations in 86 Austrian breast and ovarian cancer families (20%) that were screened for mutations by denaturing high-performance liquid chromatography (DHPLC) and the protein truncation test (PTT). Eleven distinct mutations were detected, 4 of them (962del4, 2795del4, 3135...

Topics

Adult
Austria
BRCA1 Protein
Breast Neoplasms
Carcinoma, Ductal, Breast
Carcinoma, Lobular
Carcinoma, Medullary
DNA Transposable Elements
Family
Female

Frameshift Mutation

Genes, BRCA1

Humans

Lymphatic Metastasis

Middle Aged

Mutation

Neoplasm Invasiveness

Neoplasm Staging

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