Article
Hepatitis B virus harboring nucleotide deletions in the core promoter region and genotype B correlate with low viral replication activity in anti-HBe positive carriers.
Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology - 1 Dec 2001
Li K S, Yamashiro T, Sumie A, Terao H, Mifune K, Nishizono A
Abstract excerpt
BACKGROUND: Emergence of anti-HBe following seroconversion of HBe antigen indicates reduced hepatitis B virus (HBV) replication in the liver and low infectivity in the natural course of infection. However, some patients show continued replication or reactivation even in the presence of anti-HBe. OBJECTIVE: To clarify the cause of HBV replication, we investigated genotype differences and mutations in the core...
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