Article
Replication studies in longevity: puzzling findings in Danish centenarians at the 3'APOB-VNTR locus.
Annals of human genetics - 1 Jul 2001
Varcasia O, Garasto S, Rizza T, Andersen-Ranberg K, Jeune B, Bathum L, Andreev K, Tan Q, Yashin A I, Bonafè M, Franceschi C, De Benedictis G
Abstract excerpt
In Danes we replicated the 3'APOB-VNTR gene/longevity association study previously carried out in Italians, by which the Small alleles (less than 35 repeats) had been identified as frailty alleles for longevity. In Danes, neither genotype nor allele frequencies differed between centenarians and 20-64-year-old subjects. However, when Danish and Italian data were compared, a significant difference (p = 0.0004) was...
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