Article
A study of the average effect of the 3'APOB-VNTR polymorphism on lipidemic parameters could explain why the short alleles (<35 repeats) are rare in centenarians.
BMC medical genetics - 9 Feb 2004
Garasto Sabrina, Berardelli Maurizio, DeRango Francesco, Mari Vincenzo, Feraco Emidio, De Benedictis Giovanna
Abstract excerpt
BACKGROUND: In studies on the genetics of human aging, we observed an age-related variation of the 3'APOB-VNTR genotypic pool (alleles: Short, S, <35 repeats; Medium, M, 35-39 repeats; Long, L, >39 repeats) with the homozygous SS genotype showing a convex frequency trajectory in a healthy aging population. This genotype was rare in centenarians, thus indicating that the S alleles are unfavorable to longevity,...
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