Article
HLA-DR alleles display sex-dependent effects on survival and discriminate between individual and familial longevity.
Human molecular genetics - 1 Feb 1998
Ivanova R, Hénon N, Lepage V, Charron D, Vicaut E, Schächter F
Abstract excerpt
In an effort to reassess the contribution of HLA-DRB1 polymorphisms to inter-individual variations of human longevity, we have compared their genotypic distributions between longevous and adult control groups in the French population. The longevous groups included two independent cohorts totalling 533 centenarians, and 163 nonagenarian siblings. Allelic distributions were significantly different between controls...
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