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Article

The role of the hydrophilic Asn230 residue of the mu-opioid receptor in the potency of various opioid agonists.

British journal of pharmacology - 1 Oct 2001

Pil J, Tytgat J

Abstract excerpt

1. To investigate the effect of the hydrophilic Asn amino acid at position 230 of the human mu-opioid receptor (hMOR230) on the potency of various agonists, we mutated this residue to Thr and Leu (hMORN230T and hMORN230L respectively). 2. Taking advantage of the functional coupling of the opioid receptor with the heteromultimeric G-protein-coupled inwardly rectifying K(+) (GIRK1/GIRK2) channel, either the wild...

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Identifiers

PMID: 11588103
DOI: 10.1038/sj.bjp.0704263
PMCID: PMC1572970

Genes

RGS4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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