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Article

p53-independent apoptosis mediated by tachpyridine, an anti-cancer iron chelator.

Carcinogenesis - 1 Oct 2001

Abeysinghe R D, Greene B T, Haynes R, Willingham M C, Turner J, Planalp R P, Brechbiel M W, Torti F M, Torti S V

Abstract excerpt

Iron is involved in essential biochemical reactions ranging from respiration to DNA synthesis. Consequently, iron deprivation has been proposed as a strategy for inhibition of tumor cell growth. We recently described a novel iron chelator, tachypyridine [N,N',N"-tris(2-pyridylmethyl)-cis,cis-1,3,5-triaminocyclohexane], and demonstrated that it not only inhibited growth of cultured tumor cells, but was actively...

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Identifiers

PMID: 11576999
DOI: 10.1093/carcin/22.10.1607

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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