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Article

Association of transforming growth factor-beta1 T29C polymorphism with the progression of diabetic nephropathy.

American journal of kidney diseases : the official journal of the National Kidney Foundation - 1 Oct 2001

Akai Y, Sato H, Ozaki H, Iwano M, Dohi Y, Kanauchi M

Abstract excerpt

Diabetes mellitus is a leading cause of end-stage renal disease in the Western world. Histologically, mesangial expansion with increased extracellular matrix protein is observed in patients with diabetic nephropathy. Because transforming growth factor (TGF)-beta promotes extracellular matrix production in response to high glucose, TGF-beta is considered to play a central role in the pathogenesis of diabetic...

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Identifiers

PMID: 11576951
DOI: 10.1053/ajkd.2001.27439

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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