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Article

Effects of transcription factor activator protein-1 on interleukin-8 expression and enteritis in response to Clostridium difficile toxin A.

Journal of molecular medicine (Berlin, Germany) - 1 Dec 2007

Lee Jin Young, Park Hye Ri, Oh Yu-Kyoung, Kim Yeong-Jeon, Youn Jeehee, Han Joong-Soo, Kim Jung Mogg

Abstract excerpt

Clostridium difficile toxin A causes acute colitis associated with intense infiltration of neutrophils. Although C. difficile toxin A is known to induce nuclear factor-kappaB-mediated chemokine expression in intestinal epithelial cells, little is known about its effect on the regulation of activator protein-1 (AP-1) by mitogen-activated protein kinase (MAPK). In the present study, we investigated whether the MAPK...

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PMID: 17639289
DOI: 10.1007/s00109-007-0237-7

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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