Article
Associations between a polymorphism in the gene encoding glycoprotein IIIa and myocardial infarction or coronary artery disease.
Journal of the American College of Cardiology - 1 Mar 1999
Anderson J L, King G J, Bair T L, Elmer S P, Muhlestein J B, Habashi J, Carlquist J F
Abstract excerpt
OBJECTIVES: The purpose of this study was to determine whether a common variant (PIA2) of the membrane glycoprotein (GP) IIIa gene is associated with myocardial infarction (MI) or coronary artery disease (CAD). BACKGROUND: Platelet GP IIb/IIIa is believed to play a central role in MI, binding fibrinogen, cross-linking platelets and initiating thrombus formation. Genetically determined differences in binding...
Topics
- Adolescent
- Adult
- Aged
- Aged, 80 and over
- Alleles
- Coronary Angiography
- Coronary Disease
- DNA
- DNA Primers
- Electrophoresis, Agar Gel
- Female
- Gene Frequency
- Genetic Markers
- Genotype