Associations between a polymorphism in the gene encoding glycoprotein IIIa and myocardial infarction or coronary artery disease.

doi:10.1016/s0735-1097(98)00603-2

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Associations between a polymorphism in the gene encoding glycoprotein IIIa and myocardial infarction or coronary artery disease.

Journal of the American College of Cardiology - 1 Mar 1999

Anderson J L, King G J, Bair T L, Elmer S P, Muhlestein J B, Habashi J, Carlquist J F

Abstract excerpt

OBJECTIVES: The purpose of this study was to determine whether a common variant (PIA2) of the membrane glycoprotein (GP) IIIa gene is associated with myocardial infarction (MI) or coronary artery disease (CAD). BACKGROUND: Platelet GP IIb/IIIa is believed to play a central role in MI, binding fibrinogen, cross-linking platelets and initiating thrombus formation. Genetically determined differences in binding...

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Associations between a polymorphism in the gene encoding glycoprotein IIIa and myocardial infarction or coronary artery disease.

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Associations between a polymorphism in the gene encoding glycoprotein IIIa and myocardial infarction or coronary artery disease.

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