Identification and characterization of inebriated, a gene affecting neuronal excitability in Drosophila.

Abstract excerpt

On the basis of behavioral interactions with mutations in a potassium channel gene of Drosophila--Shaker (Sh)--we have isolated mutations in a new gene called inebriated (ine). In a wildtype background, ine mutants display no observable behavioral defects. However, in a Sh mutant background, ine mutations cause downturned wings and an indented thorax. This distinctive phenotype is also exhibited by flies of other...

Topics

• Animals
• Chromosome Mapping
• Colforsin
• Drosophila
• Electrodes
• Mutagenesis
• Nerve Endings
• Neurons
• Phenotype
• Potassium Channels
• Quinidine
• Synapses